B7H6 Recombinant antibody, PBS Only

B7H6 Uni-rAb^TM Recombinant Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

240808F7

Cat no : 83908-3-PBS

Synonyms

NCR3LG1, Natural cytotoxicity triggering receptor 3 ligand 1, B7 homolog 6, B7 H6, 240808F7

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Validation Data Gallery

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  WB analysis using 83908-3-RR (same clone as 83908-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 83908-3-RR (B7H6 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83908-3-PBS in a different storage buffer formulation.

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Product Information

The immunogen of 83908-3-PBS is B7H6 Fusion Protein expressed in E. coli.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Fusion Protein
• Full Name: hypothetical protein DKFZp686O24166
• Calculated Molecular Weight: 51 kDa
• Observed Molecular Weight: 75-80 kDa
• GenBank Accession Number: BC136800
• Gene Symbol: B7H6
• Gene ID (NCBI): 374383
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

B7-H6, also known as NCR3LG1, is a member of the B7 family of immunoreceptors. It is a 454-aa-long type I transmembrane protein consisting of an extracellular region, a transmembrane segment, and a cytoplasmic domain which contains an immunoreceptor tyrosine-based inhibitory motif (ITIM), an SH2-binding domain, and an SH3-binding motif. B7-H6 triggers NKp30-mediated activation of human NK cells (PMID: 19528259). It has been reported that B7H6 is expressed in various types of tumor cells and plays a prominent role in natural killer cell immunosurveillance (PMID: 35697295). The apparent molecular weight of B7-H6 is larger than the calculated molecular weight of 51 kDa due to glycosylation (PMID: 19528259).