ATF5 Monoclonal antibody, PBS Only

ATF5 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 67066-1-PBS
Clone No.1E5B6

Host / Isotype

Mouse / IgG2b

Reactivity

Human

Applications

WB, Indirect ELISA

ATF5, ATFX, FLJ34666, HMFN0395, Transcription factor ATFx

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

67066-1-PBS targets ATF5 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen ATF5 fusion protein Ag7214 Predict reactive species
Full Name activating transcription factor 5
Calculated Molecular Weight 31 kDa
Observed Molecular Weight 30-35 kDa
GenBank Accession NumberBC005174
Gene Symbol ATF5
Gene ID (NCBI) 22809
RRIDAB_2882376
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ9Y2D1
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

ATF5, also named as Activating transcription factor 5, is a 282 amino acid protein, which belongs to the bZIP family. ATF5 is Widely expressed with higher expression levels in liver. ATF5 is actively transported to the centrosome and accumulated in the pericentriolar material (PCM) during G1 to M phase via a microtubule-dependent mechanism. During late telophase and cytokinesis, it translocates from the centrosome to the midbody (PMID: 26213385) . ATF5 as a transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically ATF5 is involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631).

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