Product Information
66830-1-PBS targets APOE in WB, IHC, IF/ICC, IF-P, FC (Intra), ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | APOE fusion protein Ag28186 Predict reactive species |
Full Name | Apolipoprotein E |
Calculated Molecular Weight | 36 kDa |
Observed Molecular Weight | 34-36 kDa |
GenBank Accession Number | BC003557 |
Gene Symbol | APOE |
Gene ID (NCBI) | 348 |
RRID | AB_2882173 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | P02649 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
The apolipoprotein E (APOE) is a 299-amino acid polypeptide that mediates the binding, internalization, and catabolism of lipoprotein particles, and also serve as a ligand for the LDL (APO B/E) receptor and for the specific APOE receptor (chylomicron remnant) of hepatic tissues. The very strong association of the APOE ɛ4 allele with AD risk and its role in the accumulation of amyloid β in brains of people and animal models solidify the biological relevance of APOE isoforms but do not provide mechanistic insight.