Product Information
85009-1-PBS targets ADAR1 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | ADAR1 fusion protein Ag5609 Predict reactive species |
| Full Name | adenosine deaminase, RNA-specific |
| Calculated Molecular Weight | 136 kDa |
| Observed Molecular Weight | 110 kDa |
| GenBank Accession Number | BC038227 |
| Gene Symbol | ADAR1 |
| Gene ID (NCBI) | 103 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purfication |
| UNIPROT ID | P55265 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
ADAR1 is also named as ADAR1, DSRAD, G1P1, IFI4. It convert selected adenosine residues into inosine in substrate RNAs containing a relatively short dsRNA region(PMID:15556947). The human ADAR1 gene specifies two size forms of RNA-specific adenosine deaminase, an IFN inducible ∼150 kDa protein and a constitutively expressed N-terminally truncated ∼110 kDa protein, encoded by transcripts with alternative exon 1 structures that initiate from different promoters(PMID:11111054). It has 5 isoforms produced by alternative promoter usage and alternative splicing. Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria (DSH).ADAR1 can form respective homodimers, and this association is essential for its enzymatic activities(PMID:17428802).
