Na 4-Hydroxynonenal Monoclonal antibody, PBS Only

4-Hydroxynonenal Monoclonal Antibody for ELISA, Indirect ELISA
Cat No. 68538-1-PBS
Clone No.2C1D10

Host / Isotype

Mouse / IgG2a

Reactivity

4-hydroxynonenal, chemical compound

Applications

ELISA, Indirect ELISA

Cas. 75899-68-2, C9H16O2, 4-Hydroxy-2-nonenal, 4-HNE

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

68538-1-PBS targets 4-Hydroxynonenal in ELISA, Indirect ELISA applications and shows reactivity with 4-hydroxynonenal, chemical compound samples.

Tested Reactivity 4-hydroxynonenal, chemical compound
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen PTG Predict reactive species
Full Name 4-Hydroxynonenal
Gene Symbol
Gene ID (NCBI)
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

4-Hydroxynonenal is a uremic toxin. Uremic toxins can be subdivided into three major groups based upon their chemical and physical characteristics: 1) small, water-soluble, non-protein-bound compounds, such as urea; 2) small, lipid-soluble and/or protein-bound compounds, such as the phenols and 3) larger so-called middle-molecules, such as beta2-microglobulin. 4-Hydroxynonenal (4-HNE) is a major aldehydic product of ω-6-unsaturated fatty acid peroxidation. It is considered a lipid peroxidation specific marker. 4-HNE has been found to induce differentiation and inhibit proliferation of HL-60 human leukemic cells. It has also been found to induce murine alveolar macrophage cell death. 4-HNE has been shown to inhibit State 3 respiration, causing a transient cytosolic Ca2+ increase. In addition, it irreversibly inhibits Na+-K+-ATPase activity.

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