Anti-Human TIM3 Rabbit Recombinant Antibody
TIM3 Uni-rAbTM Recombinant Antibody for FC
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
FC
Conjugate
Unconjugated
CloneNo.
241422H1
Cat no : 98115-1-RR
Synonyms
Validation Data Gallery
Tested Applications
Positive FC detected in | Anti-CD3/CD28 treated human PBMCs |
Recommended dilution
Application | Dilution |
---|---|
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Product Information
98115-1-RR targets TIM3 in FC applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | Recombinant Protein |
Full Name | hepatitis A virus cellular receptor 2 |
Calculated Molecular Weight | 301 aa, 33 kDa |
GenBank Accession Number | BC020843 |
Gene Symbol | TIM3 |
Gene ID (NCBI) | 84868 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
Storage Buffer | PBS with 0.09% sodium azide, pH 7.3. |
Storage Conditions | Store at 2 - 8°C. Stable for one year after shipment. |
Background Information
TIM3, also known as HAVCR2, is a member of the recently discovered T cell Ig and mucin domain-containing molecule superfamily. TIM3 is a negative regulatory molecule that is important for T cell tolerance and has a crucial role in autoimmunity and T cell exhaustion during chronic viral infection (PMID: 23180819). TIM3 is expressed by T-helper type 1 (Th1) cells, macrophage, monocyte, dendritic cells, CD8+ T cell and other lymphocyte subsets. Galectin-9 is a ligand for TIM3. TIM3-galectin-9 pathway negatively regulates T helper type 1 immunity (PMID: 16286920).
Protocols
Product Specific Protocols | |
---|---|
FC protocol for TIM3 antibody 98115-1-RR | Download protocol |
Standard Protocols | |
---|---|
Click here to view our Standard Protocols |