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TMEM106B Recombinant antibody

TMEM106B Uni-rAbTM Recombinant Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

241185F1

Cat no : 84196-1-RR

Synonyms

Transmembrane protein 106B, 241185F1

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using TMEM106B Recombinant antibody (84196-1-RR)

    WB analysis using 84196-1-RR

    Various lysates were subjected to SDS PAGE followed by western blot with 84196-1-RR (TMEM106B antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours.

Tested Applications

Positive WB detected inHeLa cells, HEK-293 cells, A549 cells, K-562 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:5000-1:50000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

84196-1-RR targets TMEM106B in WB, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Peptide
Full Name transmembrane protein 106B
Calculated Molecular Weight 31 kDa
Observed Molecular Weight75 kDa
GenBank Accession NumberBC033901
Gene Symbol TMEM106B
Gene ID (NCBI) 54664
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TMEM106B is a genetic risk factor for frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). Amyotrophic lateral sclerosis (ALS), like FTLD-TDP, is characterized by pathological TDP-43 inclusions. TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression. TMEM106B can be showed as 31-55 kDa and 70-90 kDa (Glycosylated or Dimer) form in western blot test. (PMID: 27543298, 22895706, PMID: 23136129).

Protocols

Product Specific Protocols
WB protocol for TMEM106B antibody 84196-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols