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SH2D1B Polyklonaler Antikörper

SH2D1B Polyklonal Antikörper für IHC, IF/ICC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

IHC, IF/ICC, CoIP, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 11871-1-AP

Synonyme

SH2 domain-containing protein 1B, SH2 domain containing 1B, EWS/FLI1-activated transcript 2, EAT-2, EAT2

Galerie der Validierungsdaten

Filter:
  • Immunohistochemistry (IHC) staining of human kidney tissue using SH2D1B Polyclonal antibody (11871-1-AP)

    IHC staining of human kidney using 11871-1-AP

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 11871-1-AP (SH2D1B Antibody) at dilution of 1:200 (under 10x lens).

  • Immunohistochemistry (IHC) staining of human kidney tissue using SH2D1B Polyclonal antibody (11871-1-AP)

    IHC staining of human kidney using 11871-1-AP

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 11871-1-AP (SH2D1B Antibody) at dilution of 1:200 (under 40x lens).

  • Immunofluorescence (IF) / fluorescent staining of HepG2 cells using SH2D1B Polyclonal antibody (11871-1-AP)

    IF Staining of HepG2 using 11871-1-AP

    Immunofluorescent analysis of (-20℃ Ethanol) fixed HepG2 cells using 11871-1-AP (SH2D1B antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L).

Geprüfte Anwendungen

Erfolgreiche Detektion in IHChumanes Nierengewebe
Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.
Erfolgreiche Detektion in IF/ICCHepG2-Zellen

Empfohlene Verdünnung

AnwendungVerdünnung
Immunhistochemie (IHC)IHC : 1:50-1:500
Immunfluoreszenz (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

FCSee 4 publications below
CoIPSee 1 publications below

Produktinformation

11871-1-AP bindet in IHC, IF/ICC, CoIP, ELISA SH2D1B und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
In Publikationen genannte Reaktivitäthuman
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen SH2D1B fusion protein Ag2454
Vollständiger Name SH2 domain containing 1B
Berechnetes Molekulargewicht 132 aa, 15 kDa
Beobachtetes Molekulargewicht 15 kDa
GenBank-ZugangsnummerBC022407
Gene symbol SH2D1B
Gene ID (NCBI) 117157
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SH2D1B, also named as EAT2, an adaptor expressed in innate immune cells, including natural killer (NK) cells. It plays a role in controlling signal transduction through at least four receptors, CD84, SLAMF1, LY9 and CD244, expressed on the surface of professional antigen-presenting cells. EAT-2 overexpression would enhance the innate immune responses and also result in more potent Carcinoembryonic antigen-specific adaptive immune responses.

Protokolle

Produktspezifische Protokolle
IHC protocol for SH2D1B antibody 11871-1-APProtokoll herunterladen
IF protocol for SH2D1B antibody 11871-1-APProtokoll herunterladen
FC protocol for SH2D1B antibody 11871-1-APProtokoll herunterladen
Standard-Protokolle
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen

Publikationen

SpeciesApplicationTitle
humanFC

Immunity

Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function.

Authors - Heinrich Schlums
View Article
humanFC

Immunity

Epigenetic modification and antibody-dependent expansion of memory-like NK cells in human cytomegalovirus-infected individuals.

Authors - Jaewon Lee
View Article

J Exp Med

ARID5B regulates metabolic programming in human adaptive NK cells.

Authors - Frank Cichocki
View Article

Mol Ther

Anti-NKG2C/IL-15/anti-CD33 Killer Engager Directs Primary and iPSC-derived NKG2C+ NK cells to Specifically Target Myeloid Leukemia.

Authors - Emily Chiu
View Article
human

J Immunol

Systemic Lupus Erythematosus Immune Complexes Increase the Expression of SLAM Family Members CD319 (CRACC) and CD229 (LY-9) on Plasmacytoid Dendritic Cells and CD319 on CD56dim NK Cells.

Authors - Hagberg Niklas N
View Article
humanFC,CoIP

J Immunol

T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell-Cell Contact Mediated through SLAMF6 and SAP.

Authors - Lihi Radomir
View Article