uPAR, PLAUR Recombinant antibody, PBS Only
uPAR, PLAUR Recombinant Antibody for FC, IHC, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
Human
Applications
FC, IHC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
230148A1
Cat no : 82953-1-PBS
Synonyms
Validation Data Gallery
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
82953-1-PBS targets uPAR, PLAUR in FC, IHC, Indirect ELISA applications and shows reactivity with Human samples.
Tested Reactivity | Human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | uPAR, PLAUR fusion protein Ag28056 |
Full Name | PLAUR |
Calculated Molecular Weight | 37 kDa |
GenBank Accession Number | BC002788 |
Gene Symbol | PLAUR |
Gene ID (NCBI) | 5329 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
uPAR is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)