uPAR/CD87 Monoclonal antibody, PBS Only

uPAR/CD87 Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 68727-1-PBS
Clone No.2A3E8

Host / Isotype

Mouse / IgG2b

Reactivity

human

Applications

WB, IHC, Indirect ELISA

uPAR, PLAUR, PLAUR, UPAR, U PAR, MO3

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

Please visit your regions distributor:


Product Information

68727-1-PBS targets uPAR/CD87 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen uPAR/CD87 fusion protein Ag28056 Predict reactive species
Full Name PLAUR
Calculated Molecular Weight 37 kDa
Observed Molecular Weight35-50 kDa
GenBank Accession NumberBC002788
Gene Symbol uPAR
Gene ID (NCBI) 5329
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ03405
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

uPAR is a highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)

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