• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human PDGFaa protein

Activity(Primary)

Typically ≤ 10 ng/mL EC50

Species Reactivity

human,mouse

Purity

>95%

Cat no : HZ-1215

Synonyms

PDGF 1, PDGF A, PDGF subunit A, PDGF1, PDGFA, PDGFaa



Technical Specifications

GeneID 5154
Species Human
Expression HEK293
Activity(Primary) Typically ≤ 10 ng/mL EC50
Purity >95%
Endotoxin<1 EU/μg
Accession NumberP04085
Molecular Mass 35, 40 and 45 kDa, homodimer, glycosylated
Formulation 10 mM HOAc, See Certificate of Analysis for details
Species Reactivity human,mouse

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 10 mM HOAc containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

PDGFaa is a member of the platelet-derived growth factor family. Four members of this family are mitogenic factors for cells of mesenchymal origin, and they are characterized by a motif of eight cysteines. PDGFaa plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, and chemotaxis. It is also required for a normal lung alveolar septum formation during embryogenesis, development of the gastrointestinal tract, and spermatogenesis. PDGFaa is also involved in oligodendrocyte development and l myelination process in the spinal cord and cerebellum PMID: 29408302; 29282077; 27002148).

Synonyms

PDGF 1, PDGF A, PDGF subunit A, PDGF1, PDGFA, PDGFaa

Publications

SpeciesTitle
rat

Phytomedicine

Kaempferol attenuates carbon tetrachloride (CCl4)-induced hepatic fibrosis by promoting ASIC1a degradation and suppression of the ASIC1a-mediated ERS

Authors - Rui Cao
human

Oxid Med Cell Longev

Autophagy Contributes to the Maintenance of Genomic Integrity by Reducing Oxidative Stress.

Authors - Wenqing Bu
mouse

Stem Cell Reports

Conversion of Fibroblast into Functional Leydig-like Cell Using Defined Small Molecules.

Authors - Yan Yang
mouse

Front Cell Neurosci

Nicotinamide enhances myelin production after demyelination through reduction of astrogliosis and microgliosis

Authors - Stefanos Ioannis Kaplanis