• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human IL-19 protein

Activity(Primary)

200-1000 ng/mL

Species Reactivity

human

Purity

>95%

Cat no : HZ-1332

Synonyms

NG.1, Melanoma differentiation-associated protein-like protein, Interleukin-19, MDA1, ZMDA1



Technical Specifications

GeneID 29949
Species Human
Expression HEK293
Activity(Primary) 200-1000 ng/mL
Purity >95%
Endotoxin<1 EU/μg
Accession NumberQ9UHD0
Molecular Mass 25-32 kDa reduced and non-reduced, monomer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 1x PBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix.

Background

Interleukin-19 (IL-19) is part of a smaller subfamily of interleukins that also includes IL-20, IL-22, and IL-24. These cytokines are all classified by their shared ability to bind and signal through the IL-20 receptor. IL-19 primarily exerts anti-inflammatory effects. It upregulates the production of IL-10 in PBMCs, particularly monocytes and dendritic cells and promotes the secretion of Th2-associated cytokine secretion from CD4+ T cells. It is thought to favor the polarization of naïve T cells into Th2s over Th1s, yielding a more anti-inflammatory phenotype. IL-19 also has several anti-inflammatory roles in vascular diseases, with its levels often increased in these instances to protect arteries from excessive damage (PMID: 29681905, 15827959).

Synonyms

NG.1, Melanoma differentiation-associated protein-like protein, Interleukin-19, MDA1, ZMDA1