- HEK293 expressed
- Endotoxin-free
- Animal-component free
HumanKine® recombinant human IL-11 protein
Cat no : HZ-1333
Synonyms
AGIF, Interleukin 11, Adipogenesis inhibitory factor, Oprelvekin
Validation Data Gallery
Technical Specifications
GeneID | 3589 |
Species | Human |
Expression | HEK293 |
Activity(Primary) | 10-50 ng/mL |
Purity | >95% |
Endotoxin | <1 EU/μg |
Accession Number | A8K3F7 |
Molecular Mass | 20 kDa reduced and non-reduced, monomer, glycosylated |
Formulation | 1 x PBS + 1% CHAPS, See Certificate of Analysis for details |
Species Reactivity | human |
Stability and Reconstitution
Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
---|---|---|---|
Lyophilized | -20°C to -80°C | Until Expiry Date | |
Lyophilized | Room Temperature | 2 weeks | |
Reconstituted as per CofA | -20°C to -80°C | 6 months | |
Reconstituted as per CofA | 4°C | 1 week | |
Avoid repeated freeze-thaw cycles. |
Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 1x PBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix. |
Background
Interleukin-11 (IL-11) is a member of the IL-6 family of cytokines. It is a pleiotropic cytokine that contributes to hematopoiesis, bone development, tissue remodeling, and tumor development. IL-11 binds with its receptor (IL-11RA), which is widely expressed on stromal cells including fibroblasts, smooth muscle cells, and adipocytes. It is thought to be a driver of pulmonary and dermal fibrosis. Upregulation of IL-11 has been linked to rheumatoid arthritis, ulcerative colitis, and Crohn’s disease.
Synonyms
AGIF, Interleukin 11, Adipogenesis inhibitory factor, Oprelvekin