p70(S6K) Monoclonal antibody, PBS Only
p70(S6K) Monoclonal Antibody for WB, IHC, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1D11C6
Cat no : 66638-1-PBS
Synonyms
Validation Data Gallery
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
66638-1-PBS targets p70(S6K) in WB, IHC, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.
Tested Reactivity | Human, Mouse, Rat |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | p70(S6K) fusion protein Ag5883 |
Full Name | ribosomal protein S6 kinase, 70kDa, polypeptide 1 |
Calculated Molecular Weight | 59 kDa |
Observed Molecular Weight | 60-75 kDa |
GenBank Accession Number | BC053365 |
Gene Symbol | RPS6KB1 |
Gene ID (NCBI) | 6198 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
RPS6KB1(Ribosomal protein S6 kinase beta-1) is also named as STK14A, p70 S6KA and belongs to the S6 kinase subfamily. RPS6KB1 is a major substrate of MTOR and acts as a crucial effector of MTOR signaling pathway. It plays a key role in cell growth and proliferation by regulating INS sensitivity, metabolism, protein synthesis, and cell cycle. RPS6KB1 may play an important role in the progression of HCC and could serve as a potential molecular target for HCC therapy (PMID:22684641). RPS6KB1 is a 70 kDa protein and has 5 isoforms with the calculated molecular mass of 51-59kDa produced by alternative initiation.