Product Information
66279-1-PBS targets ZEB1 in WB, IHC, ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | ZEB1 fusion protein Ag17118 Predict reactive species |
Full Name | zinc finger E-box binding homeobox 1 |
Calculated Molecular Weight | 1125 aa, 124 kDa |
Observed Molecular Weight | 190-200 kDa |
GenBank Accession Number | BC112392 |
Gene Symbol | ZEB1 |
Gene ID (NCBI) | 6935 |
RRID | AB_2881662 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P37275 |
Storage Buffer | PBS only |
Storage Conditions | Store at -80°C. |
Background Information
ZEB1(zinc-finger-enhancer binding protein 1), which is a members of the Zincfinger-Homeobox (ZFH)-family of repressors, acts as a transcriptional repressor that inhibits interleukin-2 (IL-2) gene expression. Depending on the quantity of cDNA and on the cell type, ZEB1 can enhance or repress the promoter activity of the ATP1A1 gene . Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. The calculated molecular weight of ZEB1 is 124 kDa, but the post phosphorylation of protein is about 190-210 kDa.