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- KD/KO Validated
YY1 Monoclonal antibody, PBS Only
YY1 Monoclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Host / Isotype
Mouse / IgG2a
Reactivity
human, mouse, rat, monkey
Applications
WB, IHC, IF/ICC, IP, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2E11C5
Cat no : 66281-1-PBS
Synonyms
Validation Data Gallery
Product Information
66281-1-PBS targets YY1 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat, monkey samples.
Tested Reactivity | human, mouse, rat, monkey |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Immunogen | YY1 fusion protein Ag17732 |
Full Name | YY1 transcription factor |
Calculated Molecular Weight | 414 aa, 45 kDa |
Observed Molecular Weight | 65-70 kDa |
GenBank Accession Number | BC037308 |
Gene Symbol | YY1 |
Gene ID (NCBI) | 7528 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
YY1, also named as DELTA, INO80S and NF-E1, contains four C2H2-type zinc fingers and belongs to the YY transcription factor family. YY1 is a multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the YY1. The open reading frame of the human YY1 cDNA encodes a protein of 414 amino acids with a predicted molecular weight of 44 kDa. However, YY1 migrates on SDS gels as a 65-68 kDa protein, probably due to the structure of the protein. It is a ubiquitously expressed transcription factor with fundamental roles in embryogenesis, differentiation, replication and proliferation.