- Featured Product
- KD/KO Validated
WFS1 Polyclonal antibody, PBS Only
WFS1 Polyclonal Antibody for IHC, IF/ICC, IF-P, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
IHC, IF/ICC, IF-P, Indirect ELISA
Conjugate
Unconjugated
Cat no : 26995-1-PBS
Synonyms
Validation Data Gallery
Product Information
26995-1-PBS targets WFS1 in IHC, IF/ICC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | WFS1 fusion protein Ag25724 |
Full Name | Wolfram syndrome 1 (wolframin) |
Calculated Molecular Weight | 890 aa, 100 kDa |
GenBank Accession Number | BC030130 |
Gene Symbol | WFS1 |
Gene ID (NCBI) | 7466 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Wolfram syndrome protein (WFS1), also called wolframin, is a transmembrane protein, which is located primarily in the endoplasmic reticulum and its expression is induced in response to ER stress, partially through transcriptional activation. ER localization suggests that WFS1 protein has physiological functions in membrane trafficking, secretion, processing and/or regulation of ER calcium homeostasis. It is ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations of the WFS1 gene are responsible for two hereditary diseases, autosomal recessive Wolfram syndrome and autosomal dominant low frequency sensorineural hearing loss.