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VRK2 Recombinant antibody, PBS Only (Capture)

VRK2 Uni-rAbTM Recombinant Antibody for WB, Cytometric bead array, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Cytometric bead array, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

242180B2

Cat no : 84663-1-PBS

Synonyms

Vaccinia-related kinase 2, vaccinia related kinase 2, Serine/threonine-protein kinase VRK2, EC:2.7.11.1, 242180B2

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using VRK2 Recombinant antibody (84663-1-RR)

    WB analysis using 84663-1-RR (same clone as 84663-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84663-1-RR (VRK2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84663-1-PBS in a different storage buffer formulation.

  • Cytometric bead array standard curve of MP01476-1

    Cytometric bead array standard curve of MP01476-1

    Cytometric bead array standard curve of MP01476-1, VRK2 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 84663-1-PBS. Detection antibody: 84663-2-PBS. Standard: Ag4019. Range: 1.56-100 ng/mL.

Product Information

84663-1-PBS targets VRK2 as part of a matched antibody pair:

MP01476-1: 84663-1-PBS capture and 84663-2-PBS detection (validated in Cytometric bead array)

Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen VRK2 fusion protein Ag4019
Full Name vaccinia related kinase 2
Calculated Molecular Weight 508 aa, 58 kDa
Observed Molecular Weight 58 kDa
GenBank Accession NumberBC027854
Gene Symbol VRK2
Gene ID (NCBI) 7444
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Vaccinia-related kinase 2 (VRK2) is a serine/threonine kinase that plays a significant role in various cellular processes, including cell survival, proliferation, and DNA damage response. The VRK2 gene is known to produce two main splice variants: VRK2A and VRK2B, with VRK2A being the predominant form in humans. VRK2 is involved in several key biological functions. It is known to enhance cell survival by acting as an anti-apoptotic factor, which is particularly crucial in cancer biology. The overexpression of VRK2 has been linked to increased drug sensitivity in cancer cells, suggesting that this kinase may play a role in therapeutic responses. Additionally, high levels of VRK2 protein have been associated with improved survival rates in specific subgroups of astrocytomas, a type of brain tumor. (PMID: 29872222; 37943248; 24079673)