VEGFR2 Monoclonal antibody, PBS Only
VEGFR2 Monoclonal Antibody for WB, ELISA
Host / Isotype
Mouse / IgG1
Reactivity
human
Applications
WB, ELISA
Conjugate
Unconjugated
CloneNo.
1G2A8
Cat no : 67407-1-PBS
Synonyms
Validation Data Gallery
Product Information
67407-1-PBS targets VEGFR2 in WB, ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | VEGFR2 fusion protein Ag24589 |
Full Name | kinase insert domain receptor (a type III receptor tyrosine kinase) |
Calculated Molecular Weight | 1356 aa, 152 kDa |
Observed Molecular Weight | 230 kDa |
GenBank Accession Number | BC131822 |
Gene Symbol | KDR |
Gene ID (NCBI) | 3791 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.