Uromodulin Polyclonal antibody, PBS Only

Uromodulin Polyclonal Antibody for WB, IHC, IF-P, Indirect ELISA
Cat No. 29975-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, IF-P, Indirect ELISA

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

29975-1-PBS targets Uromodulin in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Uromodulin fusion protein Ag32343 Predict reactive species
Full Name uromodulin
Calculated Molecular Weight 640 aa, 70 kDa
Observed Molecular Weight80-90 kDa
GenBank Accession NumberBC035975
Gene Symbol Uromodulin
Gene ID (NCBI) 7369
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP07911
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Uromodulin, also known as THP (Tamm-Horsfall glycoprotein), is the most abundant protein excreted in the urine under physiological conditions. Uromodulin is synthesized by the kidney and localizes in cells lining the ascending limb of Henle and distal convoluted tubule. Uromodulin has been linked to water/electrolyte balance and to kidney innate immunity. Also, studies in knockout mice demonstrated that it has a protective role against urinary tract infections and renal stone formation. Mutations in the gene encoding uromodulin lead to rare autosomal dominant diseases, collectively referred to as uromodulin-associated kidney diseases. (PMID: 21654721)

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