Product Information
12199-1-PBS targets USP25 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | USP25 fusion protein Ag2837 Predict reactive species |
Full Name | ubiquitin specific peptidase 25 |
Calculated Molecular Weight | 125 kDa |
Observed Molecular Weight | 125 kDa |
GenBank Accession Number | BC015930 |
Gene Symbol | USP25 |
Gene ID (NCBI) | 29761 |
RRID | AB_2212771 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | Q9UHP3 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Ubiquitin carboxyl-terminal hydrolase 25, encoded by USP25 gene, has three isoforms by alternative splicing. Isoform USP25a is found in most adult and fetal tissues; Isoform USP25b is found in all tissues except heart and skeletal muscle. Isoform USP25m is heart and skeletal muscle specific, and is upregulated during myogenesis, therefore, may have a role in the regulation of muscular differentiation and function. USP25, as deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates.