Product Information
68483-1-PBS targets UNC13A in WB, IHC, IF/ICC, ELISA applications and shows reactivity with Human, mouse, rat, pig, rabbit samples.
Tested Reactivity | Human, mouse, rat, pig, rabbit |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Immunogen | Peptide Predict reactive species |
Full Name | unc-13 homolog A (C. elegans) |
Calculated Molecular Weight | 193 kDa |
Observed Molecular Weight | 193-210 kDa |
GenBank Accession Number | NM_001080421 |
Gene Symbol | UNC13A |
Gene ID (NCBI) | 23025 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q9UPW8 |
Storage Buffer | PBS only |
Storage Conditions | Store at -80°C. |
Background Information
UNC13A, also named KIAA1032, belongs to the unc-13 family. It plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. UNC13A is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). It is essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. UNC13A is also involved in secretory granule priming in INS secretion. The antibody is specific to UNC13A.