UNC-2170

Synonyms

methylation, methyl-binding protein, 53BP1, H4K20me2, histone, inhibitor, DNA damage

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Application

Application: Other

Chemical Properties

MW = 349.7
C₁₄H₂₁BrN₂O • HCl
CAS 1648707-58-7
MP = 162-164°C >98% (TLC); NMR (Conforms)

Description

The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-stranded DNA breaks. UNC-2170, identified by screening, was found to be a µM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain (ref 1).

Contents

White powder. May be dissolved in DMSO (40 mg/ml); or water (50 mg/ml).

Storage Conditions

Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 3 months.

References

1. MT Perfetti et al. ACS Chem. Biol. 2015, 10:1072

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