Published Applications
| WB | See 2 publications below |
| IHC | See 2 publications below |
Product Information
13127-2-AP targets UGT1A6 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | UGT1A6 fusion protein Ag3792 Predict reactive species |
| Full Name | UDP glucuronosyltransferase 1 family, polypeptide A6 |
| Calculated Molecular Weight | 532 aa, 61 kDa |
| GenBank Accession Number | BC019861 |
| Gene Symbol | UGT1A6 |
| Gene ID (NCBI) | 54578 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P19224 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
UGT1A6 belongs to the UDP-glycosyltransferase family functioning to catalyze the transfer of glycosyl groups to lipophilic substrates, which play a key role in the inactivation and elimination of many endogenous and exogenous compounds. UGT1A6 is responsible for the glucuronida-tion of many xenobiotics and several drugs, like paracetamol, valproate,and deferiprone. It also metabolizes several important endogenous substrates such as serotonin. Polymorphisms exists in UGT1A6 gene. Studies have demonstrated very widespread variability in the expression of UGT1A6 in liver.
Publications
| Species | Application | Title |
|---|---|---|
Cancer Chemother Pharmacol Evaluation of resveratrol sensitivities and metabolic patterns in human and rat glioblastoma cells. | ||
Neurotherapeutics Diffusion Efficiency and Bioavailability of Resveratrol Administered to Rat Brain by Different Routes: Therapeutic Implications. |
