Product Information
13357-1-AP targets TULA; UBASH3A in ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | TULA; UBASH3A fusion protein Ag4170 Predict reactive species |
| Full Name | ubiquitin associated and SH3 domain containing, A |
| Calculated Molecular Weight | 74 kDa, 70 kDa |
| GenBank Accession Number | BC028138 |
| Gene Symbol | UBASH3A |
| Gene ID (NCBI) | 53347 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P57075 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
UBASH3A gene encodes ubiquitin-associated and SH3 domain-containing protein A (UBASH3A)/ Suppressor of T-cell receptor signaling 2 (STS2), also known as T-cell ubiquitin ligand 1 (TULA1) which is one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. UBASH3A gene expression is limited to only a few tissues, with its highest expression in spleen, peripheral blood leukocytes, and bone marrow. UBASH3A protein is associated with c-Cbl and ubiquitylated proteins and has been implicated in the regulation of signaling mediated by protein-tyrosine kinases oth family members can negatively regulate T-cell signaling. UBASH3A can facilitate growth factor withdrawal-induced apoptosis in T cells via its interaction with apoptosis-inducing factor (AIF).
