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  • KD/KO Validated

TUSC3 Polyclonal antibody

TUSC3 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 16039-1-AP


M33, MRT7, N33, OST3A, Protein N33, tumor suppressor candidate 3, TUSC3

Tested Applications

Positive WB detected inHeLa cells, rat testis tissue, mouse brain tissue

Recommended dilution

Western Blot (WB)WB : 1:500-1:3000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

16039-1-AP targets TUSC3 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TUSC3 fusion protein Ag8912
Full Name tumor suppressor candidate 3
Calculated Molecular Weight 347 aa, 40 kDa
Observed Molecular Weight 35-40 kDa
GenBank Accession NumberBC010370
Gene Symbol TUSC3
Gene ID (NCBI) 7991
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TUSC3 (tumor suppressor candidate 3), originally named N33, is a potential tumor supressor gene. Decreased expression of TUSC3 has been found in various cancers, including prostate cancer, pancreas cancer and ovary cancer. TUSC3 also known as OST3A, is identified as a part of the oligosaccharyl-transferase (OST) complex and plays a crucial role in protein N-glycosylation. TUSC3 mutations have been found in families with non-syndromic autosomal recessive mental retardation.


Product Specific Protocols
WB protocol for TUSC3 antibody 16039-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Nat Commun

miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC.

Authors - Young-Jun Jeon

J Cell Biol

Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

Authors - Natalia A Cherepanova
  • KD Validated

Sci Rep

Mammalian cells lacking either the cotranslational or posttranslocational oligosaccharyltransferase complex display substrate-dependent defects in asparagine linked glycosylation.

Authors - Natalia A Cherepanova
  • KD Validated

J Biol Chem

ER entry pathway and glycosylation of GPI-anchored proteins are determined by N-terminal signal sequence and C-terminal GPI-attachment sequence

Authors - Tetsuya Hirata

J Transl Med

Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma progression through LIPC/AKT axis

Authors - Ruxia Deng
  • KD Validated

J Allergy Clin Immunol

Epigenetic activation of the TUSC3 gene as a potential therapy for XMEN disease

Authors - Haodong Ding