TTK Recombinant antibody, PBS Only

TTK Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 84744-1-PBS
Clone No.241873B2

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

84744-1-PBS targets TTK in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen TTK fusion protein Ag20556 Predict reactive species
Full Name TTK protein kinase
Calculated Molecular Weight 97 kDa
Observed Molecular Weight97 kDa
GenBank Accession NumberBC000633
Gene Symbol TTK
Gene ID (NCBI) 7272
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP33981
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Mps1 family of kinases colocalizes with mitotic checkpoint proteins in kinetochores and/or spindle pole bodies/centrosomes. TTK has been shown to be a cell cycle-regulated kinase displaying maximum activity during M phase(PMID:15618221). Its kinase activity is required for proper chromosome segregation during mitosis through its involvements in microtubule-chromosome attachment error correction and the mitotic checkpoint(PMID:20937696). TTK mRNA is present at relatively high levels in testis and thymus, tissues which contain a large number of proliferating cells, but is not detected in most other benign tissues (PMID:1639825). It has 2 isoforms produced by alternative splicing (PMID:25137017).

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