Product Information
10381-1-PBS targets TTK in WB, IHC, IF/ICC, FC (Intra), IP, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | TTK fusion protein Ag0405 Predict reactive species |
Full Name | TTK protein kinase |
Calculated Molecular Weight | 97 kDa |
Observed Molecular Weight | 96-97 kDa |
GenBank Accession Number | BC000633 |
Gene Symbol | TTK |
Gene ID (NCBI) | 7272 |
RRID | AB_2211979 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | P33981 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Mps1 family of kinases colocalizes with mitotic checkpoint proteins in kinetochores and/or spindle pole bodies/centrosomes. TTK has been shown to be a cell cycle-regulated kinase displaying maximum activity during M phase(PMID:15618221). Its kinase activity is required for proper chromosome segregation during mitosis through its involvements in microtubule-chromosome attachment error correction and the mitotic checkpoint(PMID:20937696). TTK mRNA is present at relatively high levels in testis and thymus, tissues which contain a large number of proliferating cells, but is not detected in most other benign tissues (PMID:1639825). It has 2 isoforms produced by alternative splicing (PMID:25137017).