TTBK2 Recombinant antibody, PBS Only

TTBK2 Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241456B4

Cat no : 84634-1-PBS

Synonyms

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Validation Data Gallery

• 

  WB analysis using 84634-1-RR (same clone as 84634-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84634-1-RR (TTBK2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84634-1-PBS in a different storage buffer formulation.

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Product Information

The immunogen of 84634-1-PBS is TTBK2 Fusion Protein expressed in E. coli.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: TTBK2 fusion protein Ag7108
• Full Name: tau tubulin kinase 2
• Calculated Molecular Weight: 137 kDa
• Observed Molecular Weight: 137-150 kDa
• GenBank Accession Number: BC071556
• Gene Symbol: TTBK2
• Gene ID (NCBI): 146057
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

TTBK2(tau tubulin kinase 2) plays an important role in the tau cascade and in spinocerebellar degeneration. The N-terminus of TTBK2 has a serine-threonine-tyrosine kinase domain, and a C-terminal region shows homology to TTBK1. TTBK1 and TTBK2 function as regulators of TDP-43 phosphorylation. TTBK1/2 may be attractive drug targets for therapeutic interventions in TDP-43 proteinopathies such as FTLD-TDP and ALS.(PMID:25473830).