|Positive WB detected in||human placenta tissue, mouse kidney tissue, PC-3 cells|
|Positive IP detected in||mouse kidney tissue|
|Positive IF detected in||Hela cells|
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB|
|Immunofluorescence (IF)||IF : 1:10-1:100|
|Sample-dependent, check data in validation data gallery|
13411-1-AP targets TRPV6 in WB, IP, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||TRPV6 fusion protein Ag4060|
|Full Name||transient receptor potential cation channel, subfamily V, member 6|
|Calculated molecular weight||725 aa, 83 kDa|
|Observed molecular weight||83 kDa, 70 kDa|
|GenBank accession number||BC034814|
|Gene ID (NCBI)||55503|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
TRPV6, also named as CAT1 or ECaC2, is a member of the transient receptor potential (TRP) family of membrane proteins. Unlike most TRP channels, TRPV6 and its closest relative, TRPV5, are calcium-selective channels. TRPV6 is highly expressed in the proximal intestine, placenta and exocrine tissues (PMID: 12869611). It is probably involved in calcium absorption in various tissues, including calcium reabsorption in kidney. TRPV6 is overexpressed in some cancers and exhibits oncogenic potential.
J Mol Cell Cardiol
TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes.
A microengineered Brain-Chip to model neuroinflammation in humans
Mol Cancer Res
Aqueous Extract of Mori Folium Exerts Bone Protective Effect Through Regulation of Calcium and Redox Homeostasis via PTH/VDR/CaBP and AGEs/RAGE/Nox4/NF-κB Signaling in Diabetic Rats.
J Gastroenterol Hepatol
Vitamin D receptor is overexpressed in the duodenum of patients with irritable bowel syndrome.
Mol Reprod Dev
Proteomic analysis of seminal extracellular vesicle proteins involved in asthenozoospermia by iTRAQ.