Product Information
84091-4-PBS targets TRPV4 in WB, Indirect ELISA applications and shows reactivity with human, rat samples.
| Tested Reactivity | human, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | TRPV4 fusion protein Ag27253 Predict reactive species |
| Full Name | transient receptor potential cation channel, subfamily V, member 4 |
| Calculated Molecular Weight | 98 kDa |
| Observed Molecular Weight | 85~98 kDa |
| GenBank Accession Number | NM_001177428.1 |
| Gene Symbol | TRPV4 |
| Gene ID (NCBI) | 59341 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purfication |
| UNIPROT ID | Q9HBA0 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
TRPV4, also called VRL2 and VROAC, belongs to the transient receptor family and TrpV subfamily. It is a non-selective calcium permeant cation channel protein which involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. It is activated by low pH, citrate and phorbol esters. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Defects in TRPV4 are the cause of brachyolmia type 3 (BRAC3), spondylometaphyseal dysplasia Kozlowski type (SMDK) and metatropic dysplasia (MTD). Multiple transcript variants encoding different isoforms have been found.
