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TRPV4 Recombinant antibody, PBS Only

TRPV4 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241143H1

Cat no : 84091-4-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using TRPV4 Recombinant antibody (84091-4-RR)

    WB analysis using 84091-4-RR (same clone as 84091-4-PBS)

    Rat brain tissue(heated at 100 ° C and unboilded)lysates were subjected to SDS PAGE followed by western blot with 84091-4-RR (TRPV4 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84091-4-PBS in a different storage buffer formulation.

Product Information

The immunogen of 84091-4-PBS is TRPV4 Fusion Protein expressed in E. coli.

Tested Reactivity human, rat
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen TRPV4 fusion protein Ag27253
Full Name transient receptor potential cation channel, subfamily V, member 4
Calculated Molecular Weight 98 kDa
Observed Molecular Weight 85~98 kDa
GenBank Accession NumberNM_001177428.1
Gene Symbol TRPV4
Gene ID (NCBI) 59341
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

TRPV4, also called VRL2 and VROAC, belongs to the transient receptor family and TrpV subfamily. It is a non-selective calcium permeant cation channel protein which involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. It is activated by low pH, citrate and phorbol esters. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Defects in TRPV4 are the cause of brachyolmia type 3 (BRAC3), spondylometaphyseal dysplasia Kozlowski type (SMDK) and metatropic dysplasia (MTD). Multiple transcript variants encoding different isoforms have been found.