TREK1/KCNK2 Polyclonal antibody, PBS Only

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  WB analysis using 26807-1-AP (same clone as 26807-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 26807-1-AP (TREK1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 26807-1-PBS in a different storage buffer formulation.

TREK1/KCNK2 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 26807-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

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Product Information

26807-1-PBS targets TREK1/KCNK2 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: TREK1/KCNK2 fusion protein Ag25209
• Full Name: potassium channel, subfamily K, member 2
• Calculated Molecular Weight: 411 aa, 46 kDa
• Observed Molecular Weight: 40-50 kDa
• GenBank Accession Number: BC101693
• Gene Symbol: TREK1
• Gene ID (NCBI): 3776
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: O95069
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

The tandem of pore domains in a weak inward rectifying K+ channel (TWIK1, K2P1.1, or KCNK1) and TWIK-related K+channel 1 (TREK1, K2P 2.1, or KCNK2) are members of the two pore domain potassium (K2P) channel family, consisting of 15 channels that regulate the stabilization of resting membrane potential and cellular excitability by wielding background K+ leakage currents (PMID:12580339). TREK1/KCNK2 is sensitive to a wide range of physical and chemical cues. Its main role is to maintain the resting potential of the cell and whilst highly expressed in the nervous system, TREK1/KCNK2 is also expressed in the kidney, heart, lung and smooth muscle cells (PMID:31031627).