TP63 Monoclonal antibody, PBS Only
TP63 Monoclonal Antibody for WB, IHC, Indirect ELISA
Host / Isotype
Mouse / IgG2a
Reactivity
human
Applications
WB, IHC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
4D6G12
Cat no : 60332-2-PBS
Synonyms
Validation Data Gallery
Product Information
60332-2-PBS targets TP63 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Immunogen | TP63 fusion protein Ag2791 |
Full Name | tumor protein p63 |
Calculated Molecular Weight | 680 aa, 77 kDa |
Observed Molecular Weight | 70 kDa |
GenBank Accession Number | BC039815 |
Gene Symbol | TP63 |
Gene ID (NCBI) | 8626 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
TP63, also named KET, P63, P73H, P73L and TP73L, belongs to the p53 family. It is a homologue of the tumor suppressor p53 and p73 genes. It is involved in malignancy acquisition and maintenance of cells. Unlike p53, the p63 gene encodes multiple isotypes with remarkably divergent abilities to transactivate p53 reporter genes and induce apoptosis. TP63 acts as a sequence specific DNA binding transcriptional activator or repressor. TP63 has 12 isoforms with MW 40kd(P40), 50kd(P60),63kd(P63) and 73kd(P73L). It is Nuclear stain.