Product Information
66593-1-PBS targets TOM70 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.
Tested Reactivity | human, mouse, rat, pig |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Immunogen | TOM70 fusion protein Ag6027 Predict reactive species |
Full Name | translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) |
Calculated Molecular Weight | 67 kDa |
Observed Molecular Weight | 70 kDa |
GenBank Accession Number | BC052994 |
Gene Symbol | TOM70 |
Gene ID (NCBI) | 9868 |
RRID | AB_2881953 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | O94826 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
TOM70 is a mitochondrial import receptor responsible for the import of cytosol synthesized precursor proteins into the mitochondria. Tom70 is a member of the tetratricopeptide repeat (TPR) co-chaperone family and contains a conserved TPR clamp domain for interaction with Hsc70 and Hsp90. Recently overexpression of TOM70 has been linked to chemoresistance to drugs in breast cancer cell lines. It is also believed that Tom70 is significantly associated with breast cancer relapse and may predict the recurrence of ovarian cancer.