TMEM41B Recombinant antibody, PBS Only

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  WB analysis using 84510-4-RR (same clone as 84510-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84510-4-RR (TMEM41B antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84510-4-PBS in a different storage buffer formulation.

TMEM41B Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Cat No. 84510-4-PBS

Clone No.242017C11

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

Transmembrane protein 41B, KIAA0033, 242017C11

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Product Information

84510-4-PBS targets TMEM41B in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: TMEM41B fusion protein Ag30810
• Full Name: transmembrane protein 41B
• Calculated Molecular Weight: 32 kDa
• Observed Molecular Weight: 25-28 kDa
• GenBank Accession Number: BC035034
• Gene Symbol: TMEM41B
• Gene ID (NCBI): 440026
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q5BJD5
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Transmembrane protein 41B (TMEM41B), also known as Stasimon, is a major target of survival motor neuron (SMN)-dependent U12 splicing and has been identified as a protein required for motor circuit function (PMID: 23063131). TMEM41B localizes to the endoplasmic reticulum. It is involved in autophagosome biogenesis and lipid mobilization (PMID: 30126924). TMEM41B has been shown to be essential for mouse embryonic development (PMID: 30352685). Additionally, genome-scale CRISPR knockout screens reveal that TMEM41B is required for infection of flavivirus and coronavirus, including SARS-CoV-2 (PMID: 33052348; 33052332). Alternative splicing results in three transcript variants encoding distinct isoforms.