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TMEM41B Recombinant antibody, PBS Only

TMEM41B Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

242017C11

Cat no : 84510-4-PBS

Synonyms

Transmembrane protein 41B, KIAA0033, 242017C11

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using TMEM41B Recombinant antibody (84510-4-RR)

    WB analysis using 84510-4-RR (same clone as 84510-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84510-4-RR (TMEM41B antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84510-4-PBS in a different storage buffer formulation.

Product Information

The immunogen of 84510-4-PBS is TMEM41B Fusion Protein expressed in E. coli.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen TMEM41B fusion protein Ag30810
Full Name transmembrane protein 41B
Calculated Molecular Weight32 kDa
Observed Molecular Weight25-28 kDa
GenBank Accession NumberBC035034
Gene Symbol TMEM41B
Gene ID (NCBI) 440026
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Transmembrane protein 41B (TMEM41B), also known as Stasimon, is a major target of survival motor neuron (SMN)-dependent U12 splicing and has been identified as a protein required for motor circuit function (PMID: 23063131). TMEM41B localizes to the endoplasmic reticulum. It is involved in autophagosome biogenesis and lipid mobilization (PMID: 30126924). TMEM41B has been shown to be essential for mouse embryonic development (PMID: 30352685). Additionally, genome-scale CRISPR knockout screens reveal that TMEM41B is required for infection of flavivirus and coronavirus, including SARS-CoV-2 (PMID: 33052348; 33052332). Alternative splicing results in three transcript variants encoding distinct isoforms.