TLR6 Recombinant antibody, PBS Only

TLR6 Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241926A1

Cat no : 84811-1-PBS

Synonyms

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Validation Data Gallery

• 

  WB analysis of mouse brain using 84811-1-RR (same clone as 84811-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 84811-1-RR (TLR6 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84811-1-PBS in a different storage buffer formulation.

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Product Information

84811-1-PBS targets TLR6 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Peptide
• Full Name: toll-like receptor 6
• Calculated Molecular Weight: 480 aa, 56 kDa
• Observed Molecular Weight: 100 kDa
• GenBank Accession Number: BC111755
• Gene Symbol: TLR6
• Gene ID (NCBI): 10333
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

TLR6, also known as CD286, belongs to the Toll-like receptor (TLR) family which is important in the innate immune response to pathogens. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. TLR6 can form a heterodimer with TLR2. TLR6 and TLR2 are both recruited to the macrophage phagosome, where they recognize peptidoglycan, a Gram-positive pathogen component (PMID: 11095740). TLR6 interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR4. The trimeric complex is internalized and triggers an inflammatory response.