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TGM3 Polyclonal antibody, PBS Only

TGM3 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 21406-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using TGM3 Polyclonal antibody (21406-1-AP)

    WB analysis using 21406-1-AP (same clone as 21406-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21406-1-AP (TGM3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21406-1-PBS in a different storage buffer formulation.

Product Information

21406-1-PBS targets TGM3 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TGM3 fusion protein Ag16131
Full Name transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
Calculated Molecular Weight 693 aa, 77 kDa
Observed Molecular Weight77 kDa; 30-35 kDa; 44-50 kDa
GenBank Accession NumberBC109076
Gene Symbol TGM3
Gene ID (NCBI) 7053
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

TGM3 (Transglutaminase 3) is a Protein Coding gene. Diseases associated with TGM3 include Uncombable Hair Syndrome 2 and Uncombable Hair Syndrome 1. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. TG3 is expressed as an inactive 77 kDa zymogen which must be activated by limited proteolytic processing into two fragments (44 kDa and 30 kDa) of which the larger, N-terminal fragment carries the catalytic activity (PMID: 35328331).