TCF7L1/TCF7L2 Monoclonal antibody, PBS Only

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  WB analysis using 67652-1-Ig (same clone as 67652-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67652-1-Ig (TCF7L1/TCF7L2 antibody) at dilution of 1:50000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67652-1-PBS in a different storage buffer formulation.

TCF7L1/TCF7L2 Monoclonal Antibody for WB, Indirect ELISA

Cat No. 67652-1-PBS

Clone No.2B2D12

Host / Isotype

Mouse / IgG2b

Reactivity

Human, Mouse

Applications

WB, Indirect ELISA

Synonyms

HMG box transcription factor 3, HMG box transcription factor 4, TCF 3, TCF 4, TCF3, TCF4, TCF7L1, TCF7L2, Transcription factor 7 like 1

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Product Information

67652-1-PBS targets TCF7L1/TCF7L2 in WB, Indirect ELISA applications and shows reactivity with Human, Mouse samples.

• Tested Reactivity: Human, Mouse
• Host / Isotype: Mouse / IgG2b
• Class: Monoclonal
• Type: Antibody
• Immunogen: TCF7L1/TCF7L2 fusion protein Ag28954
• Full Name: transcription factor 7-like 1 (T-cell specific, HMG-box)
• Calculated Molecular Weight: 63 kDa
• Observed Molecular Weight: 70 kDa
• GenBank Accession Number: BC058894
• Gene Symbol: TCF7L1
• Gene ID (NCBI): 83439
• RRID: AB_2882851
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q9HCS4
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

TCF7L1 is one of TCF/LEF transcription factors that are mediators of the Wnt signaling pathway and are antagonized by the TGF-beta signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It's necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. This antibody raised against 1-200aa of human TCF7L1 can also react with TCF7L2.