Product Information
13251-1-AP targets TBC1D2 in ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | TBC1D2 fusion protein Ag3954 Predict reactive species |
| Full Name | TBC1 domain family, member 2 |
| Calculated Molecular Weight | 917 aa, 104 kDa |
| GenBank Accession Number | BC028918 |
| Gene Symbol | TBC1D2 |
| Gene ID (NCBI) | 55357 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9BYX2 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
TBC1D2, also known as Armus, acts as GTPase-activating protein for RAB7A, a Rab required for lysosome function. Armus is also an effector of Rac1, a small GTPase that regulates cytoskeletal remodeling, migration, and adhesion events. Upon epidermal growth factor (EGF) treatment, Armus regulates E-cadherin degradation during cell scattering but has no effect on cadherin levels at steady state. Armus mediates a crosstalk between Rac1 activation and Rab7 cycling and thus coordinates the function of these two small GTPases during cell scattering. Recently, Armus is found to play an important role in regulating autophagy.
