SYNGAP1 Recombinant antibody

SYNGAP1 {ptg:Brand} Recombinant Antibody for WB, IF/ICC, ELISA
Cat No. 85045-1-RR
Clone No.242255E3

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IF/ICC, ELISA

Synaptic Ras GTPase-activating protein 1, RASA 1, Ras/Rap GTPase-activating protein SynGAP, Ras GTPase activating protein SynGAP, Neuronal RasGAP

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

Please visit your regions distributor:


Tested Applications

Positive WB detected inmouse brain tissue, rat brain tissue
Positive IF/ICC detected inU-251 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:5000-1:50000
Immunofluorescence (IF)/ICCIF/ICC : 1:125-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

85045-1-RR targets SYNGAP1 in WB, IF/ICC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Peptide Predict reactive species
Full Name synaptic Ras GTPase activating protein 1 homolog (rat)
Calculated Molecular Weight 1343 aa, 148 kDa
Observed Molecular Weight140 kDa
GenBank Accession NumberNM_006772
Gene Symbol SYNGAP1
Gene ID (NCBI) 8831
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ96PV0
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

SYNGAP1, also named as KIAA1938, is the major constituent of the PSD essential for postsynaptic signaling. It's an inhibitory regulator of the Ras-cAMP pathway. SYNGAP1 is a member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. SYNGAP1 regulates AMPAR-mediated miniature excitatory postsynaptic currents. SYNGAP1 may be involved in certain forms of brain injury, leading to long-term learning and memory deficits Defects in SYNGAP1 are the cause of mental retardation autosomal dominant type 5 (MRD5).

Protocols

Product Specific Protocols
WB protocol for SYNGAP1 antibody 85045-1-RRDownload protocol
IF protocol for SYNGAP1 antibody 85045-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols
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