SYN2 Polyclonal antibody

SYN2 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Conjugate

Unconjugated

Publications

4

Cat no : 16573-1-AP

Synonyms

Synapsin-2, Synapsin II

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Validation Data Gallery

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  WB analysis using 16573-1-AP

  mouse brain tissue was subjected to SDS PAGE followed by western blot with 16573-1-AP (SYN2 antibody) at dilution of 1:15000 incubated at room temperature for 1.5 hours.

• 

  WB analysis of mouse brain using 16573-1-AP

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 16573-1-AP (SYN2 Antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: mouse brain tissue

Recommended dilution

• Western Blot (WB): WB : 1:5000-1:50000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• WB: See 4 publications below

Product Information

16573-1-AP targets SYN2 in WB, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Cited Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: SYN2 fusion protein Ag9855
• Full Name: synapsin II
• Calculated Molecular Weight: 582 aa, 63 kDa
• Observed Molecular Weight: 70 kDa, 55 kDa
• GenBank Accession Number: BC051307
• Gene Symbol: SYN2
• Gene ID (NCBI): 6854
• RRID: AB_2878281
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Synapsins (synapsin I, II, III) are a family of synaptic vesicle phosphoproteins that have been implicated in the modulation of neurotransmitter release and in synaptogenesis. Synapsin II (SYN2) is composed of two isoforms, synapsin IIa and IIb, , with molecular weights of 55-58 kDa and 70-75 kDa, respectively.

Publications

Species	Application	Title
mouse	WB	Brain Behav Immun; Hippocampal alpha-synuclein mediates depressive-like behaviors.; Authors - Tingfu Du
mouse	WB	Eur J Pharmacol; Investigation of rhodamine derivative on behavioral impairment in a double neurotoxin lesion of substantia nigra and locus coeruleus dysfunctional mice; Authors - Zhili Ren
human	WB	Genes Dis; The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1; Authors - Min Wang
mouse	WB	Int Immunopharmacol; pNaktide mitigates inflammation-induced neuronal damage and behavioral deficits through the oxidative stress pathway; Authors - Qinglan Zong