Product Information
66899-1-PBS targets SPTLC1 as part of a matched antibody pair:
MP50865-2: 66899-4-PBS capture and 66899-1-PBS detection (validated in Cytometric bead array)
Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | SPTLC1 fusion protein Ag7876 Predict reactive species |
| Full Name | serine palmitoyltransferase, long chain base subunit 1 |
| Calculated Molecular Weight | 53 kDa |
| Observed Molecular Weight | 55 kDa |
| GenBank Accession Number | BC007085 |
| Gene Symbol | SPTLC1 |
| Gene ID (NCBI) | 10558 |
| RRID | AB_2882228 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | O15269 |
| Storage Buffer | PBS only , pH 7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
SPTLC1 is a subunit of serine palmitoyltransferase (SPT) which is the key enzyme in sphingolipid biosynthesis and is essential for embryogenesis and cell survival. Mutations in the SPTLC1 gene (C133W, C133Y, V144D, and G387A) were reported to be responsible for the development of an inherited sensory neuropathy (hereditary sensory neuropathy type I, HSN1).
