Product Information
14609-1-PBS targets SMPD1,ASM in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | SMPD1,ASM fusion protein Ag6180 Predict reactive species |
Full Name | sphingomyelin phosphodiesterase 1, acid lysosomal |
Calculated Molecular Weight | 70 kDa |
Observed Molecular Weight | 60 kDa, 70-75 kDa |
GenBank Accession Number | BC041164 |
Gene Symbol | SMPD1 |
Gene ID (NCBI) | 6609 |
RRID | AB_2878068 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | P17405 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
SMPD1(Sphingomyelin phosphodiesterase) is also named as ASM and belongs to the acid sphingomyelinase family. It is an important enzyme in sphingolipid metabolism and plays key roles in apoptosis, immunity, development, and cancer. The deficient activity of this enzyme results in Types A and B Niemann-Pick disease (NPD). This protein has 4 isoforms produced by alternative splicing. SMPD1 can produce a 60 kDa peptide with its signal peptide missing.