Product Information
83054-5-PBS targets OATP1B1/SLCO1B1 in IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Peptide Predict reactive species |
| Full Name | solute carrier organic anion transporter family, member 1B1 |
| Calculated Molecular Weight | 76 kDa |
| GenBank Accession Number | NM_006446 |
| Gene Symbol | SLCO1B1 |
| Gene ID (NCBI) | 10599 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q9Y6L6 |
| Storage Buffer | PBS only , pH 7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
A membrane-bound sodium-independent organic anion transporter protein (OATP1B1), encoded by the SLCO1B1 gene (Solute Carrier Organic Anion Transporter Family Member 1B1), is a critical hepatic uptake transporter that plays a pivotal role in the pharmacokinetics and pharmacodynamics of numerous endogenous compounds and xenobiotics. OATP1B1 is expressed predominantly on the basolateral membrane of hepatocytes, where it mediates active intracellular hepatic transport of various anionic compounds. Polymorphisms in the gene encoding this protein are associated with impaired transporter function.
