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SLC7A2 Polyclonal antibody, PBS Only

SLC7A2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 30232-1-PBS

Synonyms

HCAT2, Cationic amino acid transporter 2, CAT-2

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using SLC7A2 Polyclonal antibody (30232-1-AP)

    WB analysis using 30232-1-AP (same clone as 30232-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30232-1-AP (SLC7A2 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30232-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human stomach cancer tissue using SLC7A2 Polyclonal antibody (30232-1-AP)

    IHC staining of human stomach cancer using 30232-1-AP (same clone as 30232-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 30232-1-AP (SLC7A2 antibody) at dilution of 1:160 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30232-1-PBS in a different storage buffer formulation.

Product Information

30232-1-PBS targets SLC7A2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen SLC7A2 fusion protein Ag31207
Full Name solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Calculated Molecular Weight 698 aa, 76 kDa
Observed Molecular Weight 76 kDa
GenBank Accession NumberBC104905
Gene Symbol SLC7A2
Gene ID (NCBI) 6542
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Solute carrier family 7 member 2 (SLC7A2), also known as CAT2, is a member of the solute carrier superfamily. It functions as a cationic amino acid transporter, which can transport cationic amino acids (arginine, lysine and ornithine) into the cytosol and regulate inflammation (PMID: 35152203). It has been shown that lower SLC7A2 expression is associated with worse prognosis of ovarian cancer and hepatocellular carcinoma (PMID: 34108444; 32647070), and SLC7A2 deficiency in inflammatory bowel tissues increases the risk of inflammation-associated colon tumorigenesis (PMID: 30202097)