SLA2 Polyclonal antibody

SLA2 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 14152-1-AP

Synonyms

Src like adapter 2, SLAP-2, SLAP2, SLAP 2, MARS

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Validation Data Gallery

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  WB analysis using 14152-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 14152-1-AP (SLA2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: human peripheral blood platelets

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

14152-1-AP targets SLA2 in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: SLA2 fusion protein Ag5334
• Full Name: Src-like-adaptor 2
• Calculated Molecular Weight: 261 aa, 29 kDa
• Observed Molecular Weight: 28-30 kDa
• GenBank Accession Number: BC042041
• Gene Symbol: SLA2
• Gene ID (NCBI): 84174
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

SLA2 is an adapter protein, which negatively regulates T-cell receptor (TCR) signaling. It Inhibits T-cell antigen-receptor-induced activation of nuclear factor of activated T-cells and may act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL-dependent degradation of signaling proteins (PMID: 11696592).