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SIRT6 Monoclonal antibody, PBS Only

SIRT6 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2H4G8

Cat no : 67510-1-PBS

Synonyms

SIR2 like protein 6, SIR2L6, SIRT6

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using SIRT6 Monoclonal antibody (67510-1-Ig)

    WB analysis using 67510-1-Ig (same clone as 67510-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67510-1-Ig (SIRT6 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67510-1-PBS in a different storage buffer formulation.

Product Information

67510-1-PBS targets SIRT6 in WB, Indirect ELISA applications and shows reactivity with Human, mouse samples.

Tested Reactivity Human, mouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen SIRT6 fusion protein Ag24103
Full Name sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
Calculated Molecular Weight 39 kDa
Observed Molecular Weight 40 kDa
GenBank Accession NumberBC028220
Gene Symbol SIRT6
Gene ID (NCBI) 51548
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

SIRT6, also named as SIR2L6, belongs to the sirtuin family. It is known to deacetylate H3K9, H3K56 and CtIP in vivo. SIRT6 regulates the expression of a large number of stress-responsive and metabolism related genes, promotes genomic stability and stimulates base excision and double strand break DNA repair(PMID: 20729089). By maintaining both the integrity and the expression of the mammalian genome, SIRT6 thus serves several roles that parallel Sir2 function(PMID: 20729089). In addtion, Sirt6-deficient animals develop normally for several weeks after birth, but succumb to an acute multi-organ degenerative syndrome that is uniformly lethal by one month of age(PMID: 19135889).