SIRT6 Monoclonal antibody, PBS Only

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  WB analysis using 67510-1-Ig (same clone as 67510-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67510-1-Ig (SIRT6 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67510-1-PBS in a different storage buffer formulation.

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  WB analysis of Jurkat using 67510-1-Ig (same clone as 67510-1-PBS)

  WB result of SIRT6 antibody (67510-1-Ig; 1:4000; incubated at room temperature for 1.5 hours) with sh-Control and sh-SIRT6 transfected Jurkat cells. This data was developed using the same antibody clone with 67510-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

SIRT6 Monoclonal Antibody for WB, Indirect ELISA

Cat No. 67510-1-PBS

Clone No.2H4G8

Host / Isotype

Mouse / IgG1

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Synonyms

NAD-dependent protein deacetylase sirtuin-6, hSIRT6, EC:2.4.2.-, EC:2.3.1.286, EC:2.3.1.-

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Product Information

67510-1-PBS targets SIRT6 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen: SIRT6 fusion protein Ag24103
• Full Name: sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
• Calculated Molecular Weight: 39 kDa
• Observed Molecular Weight: 40 kDa
• GenBank Accession Number: BC028220
• Gene Symbol: SIRT6
• Gene ID (NCBI): 51548
• RRID: AB_2882731
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein G purification
• UNIPROT ID: Q8N6T7
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

SIRT6, also named as SIR2L6, belongs to the sirtuin family. It is known to deacetylate H3K9, H3K56 and CtIP in vivo. SIRT6 regulates the expression of a large number of stress-responsive and metabolism related genes, promotes genomic stability and stimulates base excision and double strand break DNA repair(PMID: 20729089). By maintaining both the integrity and the expression of the mammalian genome, SIRT6 thus serves several roles that parallel Sir2 function(PMID: 20729089). In addtion, Sirt6-deficient animals develop normally for several weeks after birth, but succumb to an acute multi-organ degenerative syndrome that is uniformly lethal by one month of age(PMID: 19135889).