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  • KD/KO Validated

RRBP1 Polyclonal antibody

RRBP1 Polyclonal Antibody for FC, IF, IHC, WB, ELISA

Host / Isotype

Rabbit / IgG


human, mouse





Cat no : 22015-1-AP


180 kDa ribosome receptor homolog, ES/130, ES/130 related protein, ES130, hES, KIAA1398, Ribosome binding protein 1, Ribosome receptor protein, RRBP1, RRp

Tested Applications

Positive WB detected inHeLa cells, mouse pancreas tissue, HepG2 cells
Positive IHC detected inhuman lung cancer tissue, human pancreas tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inNIH/3T3 cells
Positive FC detected inBxPC-3 cells

Recommended dilution

Western Blot (WB)WB : 1:2000-1:12000
Immunohistochemistry (IHC)IHC : 1:20-1:200
Immunofluorescence (IF)IF : 1:20-1:200
Sample-dependent, check data in validation data gallery

Product Information

22015-1-AP targets RRBP1 in WB, IP, IHC, IF, FC, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen RRBP1 fusion protein Ag16648
Full Name ribosome binding protein 1 homolog 180kDa (dog)
Calculated molecular weight 1410 aa, 152 kDa
Observed molecular weight 180 kDa
GenBank accession numberBC128577
Gene symbol RRBP1
Gene ID (NCBI) 6238
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Ribosome-binding protein 1 (RRBP1) is an endoplasmic reticulum membrane protein. It is a 1410 amino acid protein composed of a hydrophobic NH2-terminus that includes a transmembrane domain, a highly conserved tandem repeat (ribosome-binding domain), and an acidic coiled-coil COOH-terminal domain. RRBP1 acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. It is also involved in early cardiac morphogenesis(PMID: 22709790; 8812507; 7686155). RRBP1 has two different isoforms with molecular weights of 150 kDa and 109 kDa.


Product Specific Protocols
WB protocol for RRBP1 antibody 22015-1-APDownload protocol
IHC protocol for RRBP1 antibody 22015-1-APDownload protocol
IF protocol for RRBP1 antibody 22015-1-APDownload protocol
FC protocol for RRBP1 antibody 22015-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Sci Adv

Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8+ T cell response in tumor.

Authors - Yuan Wang

Mol Oncol

USP35 mitigates endoplasmic reticulum stress-induced apoptosis by stabilizing RRBP1 in non-small cell lung cancer.

Authors - Wenqing Wang
  • KD Validated

Acta Biochim Biophys Sin (Shanghai)

Thymosin beta 4 silencing suppresses proliferation and invasion of non-small cell lung cancer cells by repressing Notch1 activation.

Authors - Dayu Huang

Cancer Manag Res

RRBP1 is highly expressed in prostate cancer and correlates with prognosis.

Authors - Tieqiu Li


Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function

Authors - Wonyul Jang
  • KD Validated

Front Oncol

RRBP1 depletion of bone metastatic cancer cells contributes to enhanced expression of the osteoblastic phenotype

Authors - Rui Chen
  • KD Validated