RND3 Monoclonal antibody, PBS Only

• Featured Product
• KD/KO Validated

RND3 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

human, pig

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

3H8F9

Cat no : 66228-1-PBS

Synonyms

ARHE, memB, Protein MemB, Rho family GTPase 3, Rho8, RhoE, RND3

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Validation Data Gallery

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  WB analysis of fetal human brain using 66228-1-Ig (same clone as 66228-1-PBS)

  fetal human brain tissue were subjected to SDS PAGE followed by western blot with 66228-1-Ig (RND3 Antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66228-1-PBS in a different storage buffer formulation.

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Product Information

66228-1-PBS targets RND3 in WB, Indirect ELISA applications and shows reactivity with human, pig samples.

• Tested Reactivity: human, pig
• Host / Isotype: Mouse / IgG2b
• Class: Monoclonal
• Type: Antibody
• Immunogen: RND3 fusion protein Ag18839
• Full Name: Rho family GTPase 3
• Calculated Molecular Weight: 244 aa, 27 kDa
• Observed Molecular Weight: 29 kDa
• GenBank Accession Number: BC012513
• Gene Symbol: RND3
• Gene ID (NCBI): 390
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Rnd3, also known as RhoE, belongs to the Rnd subclass of the Rho family of small guanosine triphosphate (GTP)-binding proteins. Rnd proteins are unique due to their inability to switch from a GTP-bound to GDP-bound conformation. The basic role of Rnd3 is to report as an endogenous antagonist of RhoA signaling-mediated actin cytoskeleton dynamics, which specifically contributes to cell migration and neuron polarity. Rnd3 also plays a critical role in arresting cell cycle distribution, inhibiting cell growth, and inducing apoptosis and differentiation.