RNASEL Polyclonal antibody

RNASEL Polyclonal Antibody for WB, IF, IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse and More (1)





Cat no : 22577-1-AP


2 5A dependent ribonuclease, 2 5A dependent RNase, PRCA1, Ribonuclease 4, Ribonuclease L, RNase L, RNASEL, RNS4

Tested Applications

Positive WB detected inTHP-1 cells, RAW 264.7 cells
Positive IHC detected inhuman tonsillitis tissue, human spleen tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inHepG2 cells

Recommended dilution

Western Blot (WB)WB : 1:1000-1:4000
Immunohistochemistry (IHC)IHC : 1:20-1:200
Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

22577-1-AP targets RNASEL in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen RNASEL fusion protein Ag17409
Full Name ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Calculated Molecular Weight 741 aa, 84 kDa
Observed Molecular Weight 84 kDa; 73 kDa
GenBank Accession NumberBC115697
Gene Symbol RNASEL
Gene ID (NCBI) 6041
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen Affinity purified
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

RNASEL, also named as RNS4, is an endoribonuclease that functions in the interferon (IFN) antiviral response. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. There're some isoforms with calculated MW 84 kDa and 73 kDa.


Product Specific Protocols
WB protocol for RNASEL antibody 22577-1-APDownload protocol
IHC protocol for RNASEL antibody 22577-1-APDownload protocol
IF protocol for RNASEL antibody 22577-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Nat Cell Biol

Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

Authors - Dario F De Jesus

Adv Sci (Weinh)

The CRISPR-Cas13a Gene-Editing System Induces Collateral Cleavage of RNA in Glioma Cells.

Authors - Qixue Wang

Virol Sin

IFN-β1b induces OAS3 to inhibit EV71 via IFN-β1b/JAK/STAT1 pathway

Authors - Baisong Zheng


The function of RNase L and its degradation mechanism in cardiac acute ischemic injury.

Authors - Qiang Ma

Cardiovasc Diabetol

Human serum RNase-L level is inversely associated with metabolic syndrome and age.

Authors - Yi-Ting Wang


Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression.

Authors - Yajuan Fu